In cancer lingo, “cold” tumors are cancers that the immune system doesn’t recognize or respond to, even when immune-stimulating drugs are given.
Bolt Biotherapeutics is developing drugs intended to turn cold tumors—the majority of cancers—“hot” so that other immunotherapies can work, and has raised $54 million to support its research. The Redwood City, CA, startup says its goal is to unleash the immune system in patients for whom a class of cancer immunotherapies, called checkpoint inhibitors, are ineffective. Bolt Bio says it is now working toward human tests of its lead drug.
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